Conventional cancer cell lines and animal models have been mainstays of cancer research.More recently, human pluripotent stem cells (hPSCs) and hPSC-derived organoid technologies, together with genome engineering approaches, have provided a complementary platform to model cancer progression.Here, we review the application of these technologies in c
Demands and concessions in a multi-stage bargaining process are shaped by the probabilities that each side will prevail in an impasse.Standard game-theoretic predictions are quite sharp: demands are pushed Knife to the precipice with nothing left on the table, but there is no conflict regardless of the degree of power asymmetry.Indeed, there is no
Though there Pouch is a strong consensus that word length and frequency are the most important single-word features determining visual-orthographic access to the mental lexicon, there is less agreement as how to best capture syntactic and semantic factors.The traditional approach in cognitive reading research assumes that word predictability from s
Gene expression signatures have proven their potential to characterize important cancer phenomena like oncogenic signaling pathway activities, cellular origins of tumors, or immune cell infiltration into tumor tissues.Large collections of expression signatures provide the basis for their application to data sets, but the applicability of each signa